Most people realize there is a brain gut connection. Nervous tension can aggravate irritable bowel syndrome and common dyspepsia, or stomach upset.
If the brain can upset the gut, can the gut upset the brain?
Scientists studying depression in rats think that it can.
About twenty million Americans are diagnosed with depression each year, and medical specialists believe about ten percent of the population is affected by the disease. Antidepressants are popular, but they only work for thirty five to forty five percent of patients. So, new and innovative ways to deal with the disease are being explored.
Depressed people often have gut problems, but many assume this is because hormones are released because of the depression. To determine if that is always the case, researchers tested rats to see which came first, the depression, or the gut upset.
A group of ten day old male rats were given a mild stomach irritant for six days. Others received no treatment. They were then tested at eight to ten weeks of age with water swimming challenges, and mazes. Scientists measured their responses and measured levels of stress hormones.
They found that the rats receiving the stomach irritation weeks before were more depressed than the untreated rats. Even when researchers prevented the irritant from sending pain signal to the brain, the depression occurred.
Rats are not humans, and depression is often inherited, but this research gives scientist a new avenue to follow in depression treatment. The vagus nerve connects the gut to the brain. Stimulating the nerve has been used to treat depression, epilepsy, and help memory in humans and animals. That connection may hold the secret to new treatment regimes and prevention of the disease.
大腦和內(nèi)臟之間有聯(lián)系嗎?
很多人認(rèn)為大腦和內(nèi)臟之間有聯(lián)系。神經(jīng)緊張可以加劇腸易激綜合征和常見的消化不良,或稱作是腸胃不適。
如果大腦可以使內(nèi)臟感覺不適,那內(nèi)臟可以反過來影響大腦嗎?
研究老鼠抑郁癥的科學(xué)家認(rèn)為,這是可以的。
每年,大概有兩千萬美國(guó)人被診斷為患有抑郁癥,醫(yī)學(xué)專家相信有大約十分之一的人會(huì)受抑郁癥的影響。抗抑郁藥一直暢銷,但它只對(duì)35%到45%的抑郁癥患者有效。所以,治療抑郁癥的新型療法正在探究中。
抑郁的人經(jīng)常會(huì)有內(nèi)臟疾病,但是很多人認(rèn)為這是因?yàn)橐钟舭Y導(dǎo)致的荷爾蒙分泌。為了檢驗(yàn)這種說法是否準(zhǔn)確,研究者對(duì)老鼠進(jìn)行了測(cè)驗(yàn),來驗(yàn)證到底是抑郁癥誘發(fā)內(nèi)臟不適,還是內(nèi)臟不適導(dǎo)致抑郁癥。
一組10天大的雄性老鼠連續(xù)六天接受輕度的腸胃刺激。其余的則不接受任何刺激。之后他們?cè)?到10周大時(shí)接受游泳和迷宮測(cè)試??茖W(xué)家對(duì)它們的反應(yīng)和壓力荷爾蒙的分泌情況進(jìn)行了測(cè)量。
科學(xué)家們發(fā)現(xiàn),之前幾周接受腸胃刺激的老鼠比沒有接受刺激的老鼠要更抑郁。即使當(dāng)研究者停止刺激,不再讓疼痛信息傳輸?shù)酱竽X中,抑郁癥狀仍然會(huì)發(fā)生。
老鼠與人類不同,抑郁癥通常是遺傳的。但這項(xiàng)研究為科學(xué)家在抑郁癥治療上開辟了一條新的路子。迷走神經(jīng)連接著內(nèi)臟和大腦。刺激迷走神經(jīng)已被用來治療人類和動(dòng)物的抑郁癥、癲癇病和幫助恢復(fù)記憶了。二者之間的這種聯(lián)系可能就孕育著治療和預(yù)防該疾病的新方案。